Protein Arrays : A powerful tool to detect
molecular interactions
Protein Arrays address the elucidation of molecular interaction
networks in protein complexes and in whole organisms, the screening of
drug inhibitors to study protein-protein, protein-DNA and protein-small
ligand interactions, etc ... Comparative binding affinity of wild type
and mutant proteins can be evaluated with an in-house developed
software. The binding affinity of the order 1 µM can be
monitored from attomole quantity of spotted proteins. Purified proteins
from different families can be used for array fabrication.
From
Snapyan et al., 2003, Proteomics, 3: 647-657
From Gaudin et al., 2008, Clin. & Exp Allergy
ProtNeteomix can also fabricate total protein arrays or compartiments
specific protein arrays from cell lysates or cell subfractions by the
request.
